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Document ID (ISN)110269
CIS number 09-1234
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2009
Convention or series no.
Author(s) Taeger D., Johnen G., Wiethege T., Tapio S., Möhner M., Wesch H., Tannapfel A., Müller K.M., Brüning T., Pesch B.
Title Major histopathological patterns of lung cancer related to arsenic exposure in German uranium miners
Bibliographic information July 2009, Vol.82, No.7, p.867-875. Illus. 45 ref.
Abstract A comprehensive histopathological database and a detailed job-exposure matrix developed for former German uranium miners with exposure to arsenic, radon, and quartz were analyzed to quantitatively assess the effect of arsenic regarding cell type of lung cancer. An arsenic-related increase of the proportion of squamous cell carcinoma of the lung was observed, but was restricted to miners without silicosis. The increase was found at all levels of co-exposure to radon and quartz dust. In miners with silicosis, the proportion of adenocarcinoma increased with rising arsenic exposure. Other findings are discussed.
Descriptors (primary) Germany; uranium mining; histopathology; lung cancer
Descriptors (secondary) radon; arsenic and compounds; quartz; computerized data bases; confounding factors; job-exposure relation; silicosis
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Mines and quarries
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Mining and quarrying