| Document ID (ISN) | 110252 |
| CIS number |
09-1297 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2009 |
| Convention or series no. |
|
| Author(s) |
Romeo L., Catalani S., Pasini F., Bergonzi R., Perbellini L., Apostoli P. |
| Title |
Xenobiotic action on steroid hormone synthesis and sulfonation - The example of lead and polychlorinated biphenyls |
| Bibliographic information |
Apr. 2009, Vol.82, No.5, p.557-564. Illus. 31 ref. |
| Abstract |
This study investigated the metabolism of steroid hormones to determine whether and how xenobiotics such as lead (Pb) and polychlorinated biphenyls (PCBs) interfere with steroid hormone biotransformation in humans. Three groups of subjects were tested for urinary steroids: 14 workers exposed to lead, 15 workers exposed to PCBs and an unexposed control group of 25 subjects. Findings suggest PCBs and Pb act on steroid hormone metabolism with different effects and only partially using the same hormone pathways. |
| Descriptors (primary) |
polychlorinated biphenyls; lead and compounds; toxic substances; metabolic disturbances; steroids |
| Descriptors (secondary) |
hormones; determination in urine; case-control study |
| Document type |
D - Periodical articles |
| Country / State or Province | Italy |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Endocrine diseases
Halogenated hydrocarbons
Lead and compounds
|
