Document ID (ISN) | 110238 |
CIS number |
09-1304 |
ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
Year |
2009 |
Convention or series no. |
|
Author(s) |
Garlantézec R., Monfort C., Rouget F., Cordier S. |
Title |
Maternal occupational exposure to solvents and congenital malformations: A prospective study in the general population |
Bibliographic information |
July 2009, Vol.66, No.7, p.456-463. 40 ref. |
Abstract |
To study the relations between maternal occupational exposure to solvents during pregnancy and the risk of congenital malformations, a prospective population-based cohort study was undertaken in three districts of Brittany, France, involving 3421 pregnant women. Occupational exposure to solvents at the beginning of pregnancy was assessed from the women's self-reported occupational exposures and from a job-exposure matrix. Logistic regressions were used to adjust for potential confounders. Significant associations were found between major congenital malformations and maternal occupational exposure to solvents by both self-reports and the job-exposure matrix (OR 2.48 and 3.48 respectively for the highest and lowest exposure groups). A significant dose-response trend was observed with both exposure assessment methods. Other findings are discussed. |
Descriptors (primary) |
France; solvents; expectant mothers; risk factors; teratogenic effects |
Descriptors (secondary) |
subjective assessment; parental exposure; exposure evaluation; statistical evaluation; dose-response relationship; job-exposure relation; cohort study |
Document type |
D - Periodical articles |
Country / State or Province | France |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
Chemical safety Occupational medicine, epidemiology
|
Browse category(ies) |
Genetic factors in reaction to exposures Antifertility and prenatal effects
|