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CISDOC database

Document ID (ISN)110238
CIS number 09-1304
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2009
Convention or series no.
Author(s) GarlantÚzec R., Monfort C., Rouget F., Cordier S.
Title Maternal occupational exposure to solvents and congenital malformations: A prospective study in the general population
Bibliographic information July 2009, Vol.66, No.7, p.456-463. 40 ref.
Abstract To study the relations between maternal occupational exposure to solvents during pregnancy and the risk of congenital malformations, a prospective population-based cohort study was undertaken in three districts of Brittany, France, involving 3421 pregnant women. Occupational exposure to solvents at the beginning of pregnancy was assessed from the women's self-reported occupational exposures and from a job-exposure matrix. Logistic regressions were used to adjust for potential confounders. Significant associations were found between major congenital malformations and maternal occupational exposure to solvents by both self-reports and the job-exposure matrix (OR 2.48 and 3.48 respectively for the highest and lowest exposure groups). A significant dose-response trend was observed with both exposure assessment methods. Other findings are discussed.
Descriptors (primary) France; solvents; expectant mothers; risk factors; teratogenic effects
Descriptors (secondary) subjective assessment; parental exposure; exposure evaluation; statistical evaluation; dose-response relationship; job-exposure relation; cohort study
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects