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CISDOC database

Document ID (ISN)110223
CIS number 09-1216
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2009
Convention or series no.
Author(s) Yong L.C., Sigurdson A.J., Ward E.M., Waters M.A., Whelan E.A., Petersen M.R., Bhatti P., Ramsey M.J., Ron E., Tucker J.D.
Title Increased frequency of chromosome translocations in airline pilots with long-term flying experience
Bibliographic information Jan. 2009, Vol.66, No.1, p.56-62. 40 ref.
Abstract Chromosome translocations are an established biomarker of cumulative exposure to external ionising radiation. This study determined the frequency of translocations in the peripheral blood lymphocytes of 83 airline pilots and 50 comparison subjects. Translocations were scored in an average of 1039 cell equivalents (CE) per subject using fluorescence in situ hybridisation (FISH) whole chromosome painting and expressed per 100 CE. Data were subjected to statistical analyses. There was no significant difference in the mean translocation frequency of pilots and comparison subjects. However, among pilots, the adjusted translocation frequency was significantly associated with flight years. Other findings are discussed.
Descriptors (primary) cosmic rays; USA; frequency rates; air transport; chromosome changes; aircraft
Descriptors (secondary) lymphocytes; length of service; case-control study; determination in blood; dose-response relationship; statistical evaluation; length of exposure
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Transport and communications
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Air transportation
Ionizing radiation
Genetic factors in reaction to exposures