|Document ID (ISN)||110223|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Yong L.C., Sigurdson A.J., Ward E.M., Waters M.A., Whelan E.A., Petersen M.R., Bhatti P., Ramsey M.J., Ron E., Tucker J.D.
||Increased frequency of chromosome translocations in airline pilots with long-term flying experience
||Jan. 2009, Vol.66, No.1, p.56-62. 40 ref.
||Chromosome translocations are an established biomarker of cumulative exposure to external ionising radiation. This study determined the frequency of translocations in the peripheral blood lymphocytes of 83 airline pilots and 50 comparison subjects. Translocations were scored in an average of 1039 cell equivalents (CE) per subject using fluorescence in situ hybridisation (FISH) whole chromosome painting and expressed per 100 CE. Data were subjected to statistical analyses. There was no significant difference in the mean translocation frequency of pilots and comparison subjects. However, among pilots, the adjusted translocation frequency was significantly associated with flight years. Other findings are discussed.
||cosmic rays; USA; frequency rates; air transport; chromosome changes; aircraft
||lymphocytes; length of service; case-control study; determination in blood; dose-response relationship; statistical evaluation; length of exposure
||D - Periodical articles
|Country / State or Province||USA|
||Transport and communications
|Broad subject area(s)
||Occupational medicine, epidemiology
||Antifertility and prenatal effects
Genetic factors in reaction to exposures