|Document ID (ISN)||110132|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Wen-Bin M., Wei W., Yu-Lan Q., Fang J., Zhao-Lin X.
||Micronucleus occurrence related to base excision repair gene polymorphisms in Chinese workers occupationally exposed to vinyl chloride monomer
||May 2009, Vol.51, No.5, p.578-585. 43 ref.
||This study examines whether base excision repair gene polymorphisms contributes to susceptibility of chromosomal damage induced by vinyl chloride. The cytokinesis block micronucleus test was performed on 185 vinyl chloride exposed workers to detect chromosomal changes in peripheral lymphocytes. The PCR-restriction fragment length polymorphism technique was applied to detect polymorphisms of TDG, PARP1 and APE1 genes. Univariate and multivariate Poisson regression analysis was performed. Findings are discussed. Vinyl chloride exposed workers carrying TDG 199Gly/Ser + Ser/Ser genotypes were found to be highly susceptible to chromosomal damage. A combination of TDG Gly199Ser and APE1 Ile64Val polymorphisms may modify the risk of chromosomal damage.
||vinyl chloride; risk factors; chromosome changes; DNA
||China; statistical evaluation; lymphocytes
||D - Periodical articles
|Country / State or Province||China|
||Chemicals, plastics and rubber
|Broad subject area(s)
Occupational medicine, epidemiology
||Antifertility and prenatal effects
Genetic factors in reaction to exposures