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CISDOC database

Document ID (ISN)110132
CIS number 09-1050
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2009
Convention or series no.
Author(s) Wen-Bin M., Wei W., Yu-Lan Q., Fang J., Zhao-Lin X.
Title Micronucleus occurrence related to base excision repair gene polymorphisms in Chinese workers occupationally exposed to vinyl chloride monomer
Bibliographic information May 2009, Vol.51, No.5, p.578-585. 43 ref.
Abstract This study examines whether base excision repair gene polymorphisms contributes to susceptibility of chromosomal damage induced by vinyl chloride. The cytokinesis block micronucleus test was performed on 185 vinyl chloride exposed workers to detect chromosomal changes in peripheral lymphocytes. The PCR-restriction fragment length polymorphism technique was applied to detect polymorphisms of TDG, PARP1 and APE1 genes. Univariate and multivariate Poisson regression analysis was performed. Findings are discussed. Vinyl chloride exposed workers carrying TDG 199Gly/Ser + Ser/Ser genotypes were found to be highly susceptible to chromosomal damage. A combination of TDG Gly199Ser and APE1 Ile64Val polymorphisms may modify the risk of chromosomal damage.
Descriptors (primary) vinyl chloride; risk factors; chromosome changes; DNA
Descriptors (secondary) China; statistical evaluation; lymphocytes
Document type D - Periodical articles
Country / State or ProvinceChina
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Halogenated hydrocarbons
Genetic factors in reaction to exposures