| Document ID (ISN) | 110113 |
| CIS number |
09-1112 |
| ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Year |
2009 |
| Convention or series no. |
|
| Author(s) |
Wang Y., Duan H., Dai Y., Bin P., Cheng J., Pan Z., Huang C., Leng S., Chen W., Zheng Y. |
| Title |
Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers |
| Bibliographic information |
June 2009, Vol.51, No.6, p.682-689. Illus. 56 ref. |
| Abstract |
The aim of this study was to explore the relationship between uridine diphosphoglucuronosyltransferase 1A7 (UGT1A7) gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons (PAH)-exposed workers. Blood and urine samples of 140 PAH-exposed workers and 66 non-PAH-exposed workers were collected. The polymorphisms of UGT1A7, cytokinesis-block micronucleus (CBMN) and 1-hydroxypyrene were analyzed. Findings are discussed. It is concluded that polymorphisms of UGT1A7 gene may alter the severity of PAH-induced chromosomal damage among the exposed workers. |
| Descriptors (primary) |
aromatic hydrocarbons; chromosome changes; polycyclic hydrocarbons; DNA |
| Descriptors (secondary) |
case-control study; determination in urine; determination in blood; 1-hydroxypyrene |
| Document type |
D - Periodical articles |
| Country / State or Province | China |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Antifertility and prenatal effects
Polycyclic hydrocarbons
Aromatic hydrocarbons
Genetic factors in reaction to exposures
|
