|Document ID (ISN)||110113|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Wang Y., Duan H., Dai Y., Bin P., Cheng J., Pan Z., Huang C., Leng S., Chen W., Zheng Y.
||Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers
||June 2009, Vol.51, No.6, p.682-689. Illus. 56 ref.
||The aim of this study was to explore the relationship between uridine diphosphoglucuronosyltransferase 1A7 (UGT1A7) gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons (PAH)-exposed workers. Blood and urine samples of 140 PAH-exposed workers and 66 non-PAH-exposed workers were collected. The polymorphisms of UGT1A7, cytokinesis-block micronucleus (CBMN) and 1-hydroxypyrene were analyzed. Findings are discussed. It is concluded that polymorphisms of UGT1A7 gene may alter the severity of PAH-induced chromosomal damage among the exposed workers.
||aromatic hydrocarbons; chromosome changes; polycyclic hydrocarbons; DNA
||case-control study; determination in urine; determination in blood; 1-hydroxypyrene
||D - Periodical articles
|Country / State or Province||China|
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures