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Document ID (ISN)109880
CIS number 09-890
ISSN - Serial title 1556-3650 - Clinical Toxicology
Year 2009
Convention or series no.
Author(s) Karaman A., Pirim I.
Title Exposure to bitumen fumes and genotoxic effects on Turkish asphalt workers
Bibliographic information Apr.-May 2009, Vol.47, No.4, p.321-326. Illus. 59 ref.
Abstract The aim of this study was to investigate exposure to asphalt fumes among Turkish asphalt workers and to determine whether any effects could be detected with genotoxic tests. The study included 26 asphalt workers and 24 control subjects. Sister chromatid exchange (SCE) and micronucleus (MN) were determined in peripheral lymphocytes. Urinary 1-hydroxypyrene (1-OHP) excretion was used as a biomarker of occupational exposure to PAHs. The asphalt workers had a significant increase in SCEs and MN. A positive correlation existed between the duration of exposure and rates of SCE or MN frequencies. The concentration of 1-OHP in urine was higher for the asphalt workers than for the controls. However, there was no statistically significant correlation between the urinary 1-OHP concentration and SCEs or MN frequencies.
Descriptors (primary) Turkey; toxic substances; exposure tests; genetic effects; bitumen
Descriptors (secondary) hydroxypyrenes; polycyclic hydrocarbons; determination in urine; case-control study; chromosome changes; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceTurkey
Subject(s) Construction industry
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Biological monitoring