| Document ID (ISN) | 109880 |
| CIS number |
09-890 |
| ISSN - Serial title |
1556-3650 - Clinical Toxicology |
| Year |
2009 |
| Convention or series no. |
|
| Author(s) |
Karaman A., Pirim I. |
| Title |
Exposure to bitumen fumes and genotoxic effects on Turkish asphalt workers |
| Bibliographic information |
Apr.-May 2009, Vol.47, No.4, p.321-326. Illus. 59 ref. |
| Abstract |
The aim of this study was to investigate exposure to asphalt fumes among Turkish asphalt workers and to determine whether any effects could be detected with genotoxic tests. The study included 26 asphalt workers and 24 control subjects. Sister chromatid exchange (SCE) and micronucleus (MN) were determined in peripheral lymphocytes. Urinary 1-hydroxypyrene (1-OHP) excretion was used as a biomarker of occupational exposure to PAHs. The asphalt workers had a significant increase in SCEs and MN. A positive correlation existed between the duration of exposure and rates of SCE or MN frequencies. The concentration of 1-OHP in urine was higher for the asphalt workers than for the controls. However, there was no statistically significant correlation between the urinary 1-OHP concentration and SCEs or MN frequencies. |
| Descriptors (primary) |
Turkey; toxic substances; exposure tests; genetic effects; bitumen |
| Descriptors (secondary) |
hydroxypyrenes; polycyclic hydrocarbons; determination in urine; case-control study; chromosome changes; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Turkey |
| Subject(s) |
Construction industry
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Antifertility and prenatal effects
Genetic factors in reaction to exposures
Biological monitoring
|
