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CISDOC database

Document ID (ISN)109877
CIS number 09-886
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2009
Convention or series no.
Author(s) Lessmann H., Uter W., Schnuch A., Geier J.
Title Skin sensitizing properties of the ethanolamines mono-, di-, and triethanolamine. Data analysis of a multicentre surveillance network (IVDK*) and review of the literature
Bibliographic information May 2009, Vol.60, No.5, p.243-255. 83 ref.
Abstract Numerous publications address the skin sensitizing potential of the short chain alkanolamines triethanolamine (TEA), diethanolamine (DEA), monoethanolamine (MEA), which are not skin sensitizing according to animal studies. In this work, data of the literature on MEA, DEA and TEA as well as data of a multicentre surveillance network were analyzed. For TEA, patch test data of 85,098 patients were examined. Altogether, 323 patients (0.4%) tested positive. The profile of patch test reactions indicates a slightly irritant potential rather than a true allergic response in many cases. The risk of sensitization to TEA seems to be very low. For MEA and DEA, patch tests in 9602 and 8791 patients, respectively revealed a prevalence of contact allergy of 3.8% and 1.8%. Chronic damage to the skin barrier, the alkalinity of ethanolamines and other cofactors may contribute to a notable sensitization risk.
Descriptors (primary) ethanolamine; diethanolamine; sensitization; skin allergies; triethanolamine
Descriptors (secondary) skin tests; literature survey
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Allergies
Skin diseases