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Document ID (ISN)109871
CIS number 09-885
ISSN - Serial title 0019-8366 - Industrial Health
Year 2009
Convention or series no.
Author(s) Xu X., Yang R., Wu N, Zhong P., Ke Y., Zhou L., Yuan J., Li G., Huang H, Wu B.
Title Severe hypersensitivity dermatitis and liver dysfunction induced by occupational exposure to trichloroethylene
Bibliographic information Mar. 2009, Vol.47, No.2, p.107-112. Illus. 33 ref.
Internet access http://www.jstage.jst.go.jp/article/indhealth/47/2/107/_pdf/-char/ja/ [in English]
Abstract This study examines trichloroethylene (TCE)-induced dermatitis in 21 patients and investigates their occupational exposure as well as their clinical features. TCE concentrations in the workplace air were also monitored. Additionally, the symptoms, signs and laboratory test results of patients were collected. TCE concentrations in the cleaning agent used in the industries in which the patients worked varied from 10.2% to 91.4% by gas chromatography-mass chromatography analysis, and TCE levels in the workplace air ranged between 18 and 683 mg/m3. Most patients had symptoms such as headache (90.5%), dizziness (100%), skin itch (100%), fever (61.9%), skin erythema (85.7%) and rashes (90.5%). In addition, liver enlargement occurred in 3 patients; the abnormal rate of alanine aminotransferase, aspartate aminotransferase, total bilirubin were 90.5%, 85.7% and 76.2%, respectively. Taken together, the major detrimental effect of trichloroethylene was to induce hypersensitivity dermatitis and liver dysfunction, the occurrence of this disorder being most likely related to the individual hypersensitivity to TCE exposure.
Descriptors (primary) China; sensitization dermatitis; domestic and related helpers, cleaners; trichloroethylene; transaminases; hepatotoxic effects
Descriptors (secondary) hepatic disorders; determination in air; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceChina
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Skin diseases
Halogenated hydrocarbons
Domestic workers