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CISDOC database

Document ID (ISN)109737
CIS number 09-554
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2008
Convention or series no.
Author(s) Hewitt D.J.
Title Interpretation of the "positive" methacholine challenge
Bibliographic information Oct. 2008, Vol.51, No.10, p.769-781. Approx. 120 ref.
Abstract This article reviews potential causes of a positive methacholine challenge other than asthma or reactive airways dysfunction syndrome which have been reported in the medical literature. Factors which may be associated with a positive methacholine test include test methodology, normal variation of bronchial hyperreactivity in the general population and numerous medical conditions. In cases of inhalation exposure evaluations, alternative explanations must be considered when determining whether a causal association exists between the exposure and a positive methacholine test result.
Descriptors (primary) methacholine; inhalation; allergy tests; diagnosis; asthma
Descriptors (secondary) literature survey; obstructive ventilatory impairment; allergic reactivity; hypersensitivity; description of technique; reliability
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)