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Document ID (ISN)109542
CIS number 09-626
ISSN - Serial title 1556-3650 - Clinical Toxicology
Year 2009
Convention or series no.
Author(s) Pizon A.F., Schwartz A.R., Shum L.M., Rittenberger J.C., Lower D.R., Giannoutsos S., Virji M.A., Krasowski M.D.
Title Toxicology laboratory analysis and human exposure to p-chloroaniline
Bibliographic information Feb. 2009, Vol.47, No.2, p.132-136. Illus. 12 ref.
Abstract A 20 year-old man working at a chemical waste plant developed dizziness, abdominal pain and nausea. Following medical examinations which revealed cyanosis and methaemoglobinaemia, methylene blue administration led to complete recovery without sequelae. p-Chloroaniline was later identified as the chemical involved. The subject denied direct contact with the chemical, but was not wearing a respirator during work. GC/MS (gas chromatography-mass spectrometry) confirmed p-chloroaniline and its primary metabolite, p-chloroacetanilide, in the patient's urine.
Descriptors (primary) p-chloroaniline; toxicology; methaemoglobinaemia; chemical products; waste disposal; hypoxia
Descriptors (secondary) airborne dust; mass spectrometry; case study; metabolic process; determination in urine; diagnosis; respirators; sampling and analysis; gas chromatography; methylene blue
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Waste collection and disposal
Diseases of the respiratory system (except for pneumoconiosis & similar)