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CISDOC database

Document ID (ISN)109497
CIS number 09-404
ISSN - Serial title 1059-924X - Journal of Agromedicine
Year 2008
Convention or series no.
Author(s) McCauley L.A., Lasarev M., Muniz J., Nazar Stewart V., Kisby G.
Title Analysis of pesticide exposure and DNA damage in immigrant farmworkers
Bibliographic information 2008, Vol.13, No.4, p.237-246. Illus. 33 ref.
Abstract This study was designed to use the comet assay to describe the association of markers of DNA damage in oral leukocytes with biomarkers of pesticide exposure. It involved 134 farmworkers working in berry crops in the U.S. State of Oregon and 55 non exposed controls. It also examined the extent of DNA damage in young workers compared to adults and the effect of work histories, lifestyle factors, and diet on markers of DNA damage. Tail intensity and tail moment were significantly higher for agricultural workers compared to controls. However no parameter was significantly associated with years spent working in agriculture, age, sex, body mass index, diet, and alcohol or tobacco use. The results of this study demonstrate the feasibility for using the comet assay in biomonitoring studies of farmworkers.
Descriptors (primary) leukocytes; Oregon; organophosphorus compounds; agriculture; pesticides; insecticides; DNA
Descriptors (secondary) captan; USA; reliability; determination in urine; case-control study; description of technique; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Agriculture, fishing, animal husbandry
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Agriculture
Agricultural chemicals