Document ID (ISN) | 109373 |
CIS number |
09-323 |
ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
Year |
2009 |
Convention or series no. |
|
Author(s) |
van Rooy F.G.B.G.J., Smit L.A.M., Houba R., Zaat V.A.C., Rooyackers J.M., Heederik D.J. |
Title |
A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings |
Bibliographic information |
Feb. 2009, Vol.66, No.2, p.105-110. Illus. 16 ref. |
Abstract |
Four workers of a diacetyl (also known as 2,3-butanedione) plant in the Netherlands were diagnosed with a bronchiolitis obliterans syndrome. This lead to an investigation of exposures, respiratory symptoms, lung function and exposure-response relationships in a cohort of 175 workers having worked at the plant between 1960 and 2003. Lung function and questionnaire data on respiratory symptoms were compared to a general population sample and to an unexposed internal reference group. Compared to the two reference groups, diacetyl exposed workers reported significantly more respiratory symptoms, daily cough and asthma. A relationship between exposure and FEV1 was also observed. The excess of respiratory symptoms in this retrospective cohort suggests that diacetyl production poses an occupational hazard. |
Descriptors (primary) |
chemical industry; ketones; risk factors; respiratory diseases; food additives; 2,3-butanedione |
Descriptors (secondary) |
Netherlands; symptoms; dyspnoea; asthma; respiratory function tests; questionnaire survey; cohort study; cross-sectional study; one-second forced expiratory volume |
Document type |
D - Periodical articles |
Country / State or Province | Netherlands |
Subject(s) |
Chemicals, plastics and rubber
|
Broad subject area(s) |
Chemical safety Occupational medicine, epidemiology
|
Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar) Ketones Chemical industry
|