|Document ID (ISN)||109373|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||van Rooy F.G.B.G.J., Smit L.A.M., Houba R., Zaat V.A.C., Rooyackers J.M., Heederik D.J.
||A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings
||Feb. 2009, Vol.66, No.2, p.105-110. Illus. 16 ref.
||Four workers of a diacetyl (also known as 2,3-butanedione) plant in the Netherlands were diagnosed with a bronchiolitis obliterans syndrome. This lead to an investigation of exposures, respiratory symptoms, lung function and exposure-response relationships in a cohort of 175 workers having worked at the plant between 1960 and 2003. Lung function and questionnaire data on respiratory symptoms were compared to a general population sample and to an unexposed internal reference group. Compared to the two reference groups, diacetyl exposed workers reported significantly more respiratory symptoms, daily cough and asthma. A relationship between exposure and FEV1 was also observed. The excess of respiratory symptoms in this retrospective cohort suggests that diacetyl production poses an occupational hazard.
||chemical industry; ketones; risk factors; respiratory diseases; food additives; 2,3-butanedione
||Netherlands; symptoms; dyspnoea; asthma; respiratory function tests; questionnaire survey; cohort study; cross-sectional study; one-second forced expiratory volume
||D - Periodical articles
|Country / State or Province||Netherlands|
||Chemicals, plastics and rubber
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the respiratory system (except for pneumoconiosis & similar)