|Document ID (ISN)||109344|
|Convention or series no.
||Concise International Chemical Assessment Document 74
||Kielhorn J., Mangelsdorf I., Ziegler-Skylakakis K.
||World Health Organization, Distribution and Sales Service,1211 Genève 27, Switzerland, 2008. v, 47p. Illus. Approx. 200 ref.
||http://www.who.int/ipcs/publications/cicad/cicad74.pdf [in English]
||Conclusions of this criteria document: 2-Butenal causes irritation and inflammation of the skin, respiratory tract and eyes in humans and experimental animals. Its strong odour and irritancy may limit exposure to this substance. Most studies identified a genotoxic potential of 2-butenal. Positive results were found in a range of in vitro tests for genotoxicity. Owing to a lack of reliable data, it is not possible to adequately evaluate the toxicity of 2-butenal in humans or to derive a tolerable concentration. Summaries in French and in Spanish.
||WHO; crotonaldehyde; ecotoxicology; toxicology; aliphatic aldehydes
||mutagenic effects; irritants; ILO; UNEP; genetic effects; fungicides; animal experiments; in vitro experiments; inhalation
||E - Books, reports, proceedings
|Country / State or Province||WHO|
||Toxic and dangerous substances
|Broad subject area(s)
||Genetic factors in reaction to exposures