| Document ID (ISN) | 109320 |
| CIS number |
09-406 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
2007 |
| Convention or series no. |
|
| Author(s) |
Monteiller C., Tran L., MacNee W., Faux S., Jones A., Miller B., Donaldson K. |
| Title |
The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: The role of surface area |
| Bibliographic information |
Sep. 2007, Vol.64, No.9, p.609-615. Illus. 47 ref. |
| Abstract |
Mass might not be the appropriate metric for regulating exposures to low-solubility low-toxicity particles (LSLTPs) as animal studies have shown that nanoparticles produce a stronger adverse effect than fine particles when delivered on an equal mass basis. This study investigated whether the surface area is a better descriptor than mass of LSLTP of their ability to stimulate pro-inflammatory responses in vitro. In assays on a human alveolar type II-like cell line, nanoparticle preparations produced much stronger inflammatory responses than the same mass of fine particles of the same chemical composition. Oxidative stress was involved in the response to all the particles. Dose-response relationships appeared to be directly comparable with those found in vivo. These findings show that surface area is a more appropriate dose metric than mass for the pro-inflammatory effects of LSLTP and that the high surface area of nanoparticles is a key factor in their inflammogenicity. |
| Descriptors (primary) |
toxic effects; nanoparticles; particle surface area; in vitro experiments; inflammations; toxicity evaluation; particle size |
| Descriptors (secondary) |
interleukins; glutathione; quartz; titanium dioxide; animal experiments; cell culture; dose-response relationship; carbon black |
| Document type |
D - Periodical articles |
| Country / State or Province | United Kingdom |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Nanotechnology and nanoparticles
|
