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Document ID (ISN)109292
CIS number 09-325
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Magnani C., Ferrante D., Barone-Adesi F., Bertolotti M., Todesco A., Mirabelli D., Terracini B.
Title Cancer risk after cessation of asbestos exposure: A cohort study of Italian asbestos cement workers
Bibliographic information Mar. 2008, Vol.65, No.3, p.164-170. 36 ref.
Abstract This study examines the mortality for asbestos-related diseases and the incidence of mesothelioma in a cohort of Italian asbestos cement workers after cessation of asbestos exposure. The factory operated from 1907 to 1986. The cohort included 3,434 subjects active in 1950 or hired in 1950-86. Local reference rates were used for both mortality and mesothelioma incidence. Mortality was increased in both sexes for all causes, pleural and peritoneal malignancies and lung cancer. In women, ovarian and uterine malignancies were also in excess. No statistically significant increase was found for laryngeal cancer. This study of a cohort of asbestos exposed workers with very long follow-up confirmed the reduction in risk of death from lung cancer after the end of exposure. It also showed a different risk pattern for pleural and peritoneal mesothelioma: a reduction in risk for pleural mesothelioma with over 40 years of latency, while risk for peritoneal mesothelioma showed a continuing increase.
Descriptors (primary) mesothelioma; Italy; asbestos cement industry; cancer; asbestos
Descriptors (secondary) ovarian cancer; latency; mortality; pleural mesothelioma; lung cancer; frequency rates; peritoneal mesothelioma; hazard evaluation; cohort study; long-term study; sex-linked differences; uterine cancer
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Materials, glass and ceramics
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Asbestos
Cement and concrete