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Document ID (ISN)109227
CIS number 09-158
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Nuernberg A.M., Boyce P.D., Cavallari J.M., Fang S.C., Eisen E.A., Christiani D.C.
Title Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure
Bibliographic information Feb. 2008, Vol.50, No.2, p.182-189. Illus. 35 ref.
Abstract To investigate the association of exposure to fine particulate matter (PM 2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes, 41 workers were monitored over 24 hours during which baseline, post-shift, bedtime, and next morning urine samples were collected. Blood samples were also collected pre-shift and the following morning. Twenty-two unexposed workers participated as controls. Linear regression was used to model changes in u-8-isoprostane and u-8-OHdG. Acute welding fume exposure was found to be associated with a post-shift blunting of systemic inflammation, as measured by 8-isoprostane, in chronically exposed workers. The level of oxidative DNA damage as measured by 8-OHdG was less clear.
Descriptors (primary) DNA; respirable dust; welding and cutting; boilermaking; exposure tests; welding fumes
Descriptors (secondary) exposure evaluation; case-control study; determination in urine; determination in blood; statistical evaluation
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Welding and cutting
Metalworking industry