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Document ID (ISN)109217
CIS number 09-51
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Franko A., Dolžan V., Arnerić N., Dodič-Fikfak M.
Title The influence of genetic polymorphisms of GSTP1 on the development of asbestosis
Bibliographic information Jan. 2008, Vol.50, No.1, p.7-12. 29 ref.
Abstract Genetic factors are believed to play an important role in the development of asbestosis. The aim of this study was to investigate whether genetic polymorphisms of glutathione S-transferase (GST) P1 represent a risk factor for this disease. The study population included 262 workers with asbestosis and 265 matched controls. Information on cumulative asbestos exposure was available. A real-time PCR based on the 5' nuclease assay was designed for the analysis of the GSTP1 polymorphisms. The key finding was that GSTP1 genotype coding for an enzyme with high conjugation capacity versus genotypes resulting in intermediate and low enzyme activity significantly increases the risk of asbestosis (odds ratio 1.49).
Descriptors (primary) asbestos; glutathione transferase; risk factors; genetic effects; asbestosis
Descriptors (secondary) case-control study; DNA
Document type D - Periodical articles
Country / State or ProvinceSlovenia
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures