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Document ID (ISN)109179
CIS number 09-160
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2008
Convention or series no.
Author(s) J÷nsson L.S., J÷nsson B.A.G., Axmon A., Littorin M., Broberg K.
Title Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries
Bibliographic information July 2008, Vol.81, No.7, p.913-919. Illus. 36 ref.
Abstract The aim of this study was to elucidate the role of genetic variants on symptoms of the eyes and airways, headache and nausea, as well as on immunologic markers, among vulcanization workers in the Swedish rubber industry. Polymorphisms in genes, which are involved in the defence against reactive oxygen species and metabolism of toxic substances present in the vulcanization fumes, were analysed. A total of 145 exposed and 117 unexposed workers were included in the study. Data concerning symptoms and medical and occupational histories were obtained in structured interviews. Immunologic markers were analysed in blood. Polymorphisms in glutathione-related genes were analysed by TaqMan allelic discrimination and polymerase chain reaction. Findings are discussed. It is concluded that hereditary factors may influence the susceptibility to symptoms and the immunologic response of rubber industry workers.
Descriptors (primary) rubber industry; glutathione; symptoms; individual susceptibility; genetic effects; immunogenic factors; vulcanization
Descriptors (secondary) Sweden; DNA; antioxidants; determination in blood; immunology
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Rubber industry
Genetic factors in reaction to exposures