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Document ID (ISN)109128
CIS number 09-38
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Hintsanen M., Elovainio M., Puttonen S., Kivimäki M., Lehtimäki T., Kähönen M., Juonala M., Rontu R., Viikari J.S.A., Raitakari O.T., Keltikangas-Järvinen L.
Title Val/met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men
Bibliographic information June 2008, Vol.50, No.6, p.649-657. Illus. 51 ref.
Abstract Several studies support job strain as a risk factor for coronary heart disease (CHD). Since the COMT gene influences dopamine transmission, dopaminergic activity might moderate effects of stress on CHD risk. This study examines whether COMT Val158Met polymorphism moderates the association between job strain and atherosclerosis. Participants were 347 women and 353 men from the population-based Young Finns study. Preclinical atherosclerosis was measured using carotid intima-media thickness (IMT) ultrasound. The COMT polymorphism was found to moderate the job strain-IMT association in men. The findings support a general model in which the interaction between genotype and job strain is assumed to predispose to increased atherosclerotic processes.
Descriptors (primary) atherosclerosis; stress factors; young persons; risk factors; genetic effects
Descriptors (secondary) Finland; DNA; ultrasonic examinations; individual susceptibility; sex-linked differences
Document type D - Periodical articles
Country / State or ProvinceFinland
Subject(s) Psychology and sociology
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Cardiovascular diseases
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Mental stress and burnout