|Document ID (ISN)||109128|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Hintsanen M., Elovainio M., Puttonen S., Kivimäki M., Lehtimäki T., Kähönen M., Juonala M., Rontu R., Viikari J.S.A., Raitakari O.T., Keltikangas-Järvinen L.
||Val/met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men
||June 2008, Vol.50, No.6, p.649-657. Illus. 51 ref.
||Several studies support job strain as a risk factor for coronary heart disease (CHD). Since the COMT gene influences dopamine transmission, dopaminergic activity might moderate effects of stress on CHD risk. This study examines whether COMT Val158Met polymorphism moderates the association between job strain and atherosclerosis. Participants were 347 women and 353 men from the population-based Young Finns study. Preclinical atherosclerosis was measured using carotid intima-media thickness (IMT) ultrasound. The COMT polymorphism was found to moderate the job strain-IMT association in men. The findings support a general model in which the interaction between genotype and job strain is assumed to predispose to increased atherosclerotic processes.
||atherosclerosis; stress factors; young persons; risk factors; genetic effects
||Finland; DNA; ultrasonic examinations; individual susceptibility; sex-linked differences
||D - Periodical articles
|Country / State or Province||Finland|
||Psychology and sociology
|Broad subject area(s)
||Occupational medicine, epidemiology
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Mental stress and burnout