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CISDOC database

Document ID (ISN)109127
CIS number 09-37
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Yucesoy B., Kurzius-Spencer M., Johnson V.J., Fluharty K., Kashon M.L., Guerra S., Luster M.I., Burgess J.L.
Title Association of cytokine gene polymorphisms with rate of decline in lung function
Bibliographic information June 2008, Vol.50, No.6, p.642-648. 37 ref.
Abstract The objective of this study was to investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in one-second forced expiratory volume (FEV1). Gene polymorphisms were investigated in 374 active firefighters for whom the data of at least five pulmonary function tests were available. Findings are discussed. It is concluded that inter-individual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.
Descriptors (primary) fire fighting; genetic effects; pulmonary function
Descriptors (secondary) USA; DNA; individual susceptibility; respiratory function tests; age-linked differences; one-second forced expiratory volume
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures