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Document ID (ISN)109115
CIS number 09-139
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Hamaguchi T., Omae K., Takebayashi T., Kikuchi Y., Yoshioka N., Nishiwaki Y., Tanaka A., Hirata M., Taguchi O., Chonan T.
Title Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage
Bibliographic information Jan. 2008, Vol.65, No.1, p.51-55. Illus. 24 ref.
Abstract The objective of this case-control study was to identify the effects of indium on the lung and to assess possible dose-response relationships. It involved 93 male indium-exposed and 93 male non-exposed workers from four indium and tin oxide manufacturing and recycling plants. Indium in serum (In-S) was determined as a biomarker of exposure. Geometric means of In-S were 8.25ng/ml in the exposed workers and 0.25ng/ml in the non-exposed workers. The maximum concentration of In-S was 116.9ng/ml. Data on respiratory symptoms and job histories were obtained by means of questionnaires. Participants were also subjected to spirometry, high-resolution computerised tomography (HRCT) of the chest, serum KL-6, serum SP-A, serum SP-D and serum CRP. Serum biomarkers and HRCT indicate that exposure to hardly-soluble indium compound dust may represent a risk for interstitial lung damage. Other findings are discussed.
Descriptors (primary) indium and compounds; tin oxide; risk factors; pulmonary fibrosis; metalworking industry; Japan
Descriptors (secondary) airborne dust; subjective assessment; symptoms; respiratory diseases; respirable dust; tomography; case-control study; spirometry; determination in blood; medical examinations; exposure tests; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Metalworking industry
Inorganic substances