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CISDOC database

Document ID (ISN)109090
CIS number 09-31
ISSN - Serial title 1059-924X - Journal of Agromedicine
Year 2008
Convention or series no.
Author(s) Dhillon A.S., Tarbutton G.L., Levin J.L., Plotkin G.M., Lowry L.K., Nalbone J.T., Shepherd S.
Title Pesticide/environmental exposures and Parkinson's disease in East Texas
Bibliographic information 2008, Vol.13, No.1, p.37-48. 62 ref.
Abstract Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9) and any rotenone use in the past (OR = 10.0), the use of chlorpyrifos products (OR = 2.0), past work in an electronics plant (OR = 5.1), and exposure to fluorides (OR = 3.3). Cigarette smoking, alcohol use and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population.
Descriptors (primary) pesticides; Parkinson's disease
Descriptors (secondary) chlorpyrifos; fluorides; rotenone; paper and paper products industry; case-control study; electronics industry; smoking
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the nervous system
Electronics industry
Agricultural chemicals