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Document ID (ISN)109060
CIS number 09-165
ISBN(s) 978-92-4-156360-4
Year 2008
Convention or series no. Harmonization Project Document No.5
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
Title Skin sensitization in chemical risk assessment
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 GenŔve 27, Switzerland, 2008. iv, 85p. Illus. Bibl.ref.
Internet access [in English]
Abstract This harmonization project activity in 2006 focused on skin sensitization in chemical risk assessment. An IPCS international workshop was convened from 17-18 October 2006, in Berlin, Germany with the aim of evaluating experimental techniques for their ability to produce data to inform risk assessment, including provision of dose-response information and information relating to sensitive sub-populations. The workshop focused on whether it is possible to distinguish between chemicals with a high potency to elicit allergic skin reactions and those with a low potency. Emerging approaches, such as structure activity relationships (SAR), were explored. The meeting also explored whether assessment approaches for skin sensitization could inform approaches for the respiratory tract.
Descriptors (primary) WHO; skin allergies; skin tests; chemical products; hazard evaluation; sensitizers
Descriptors (secondary) allergens; IPCS; sensitization; dose-response relationship; conference; reliability
Document type E - Books, reports, proceedings
Country / State or ProvinceWHO
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases
Risk evaluation