|Document ID (ISN)||108997|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Interpretation of the "positive" methacholine challenge
||Oct. 2008, Vol.51, No.10, p.769-781. Approx. 120 ref.
||The methacholine challenge test is used in confirming the diagnosis of asthma, occupational asthma or reactive airways dysfunction syndrome (RADS) through the identification of bronchial hyperreactivity (BHR). While the sensitivity of the test in diagnosing clinically significant asthma is excellent, its specificity is poor. Since there are many conditions which have been associated with BHR, a positive test must be interpreted cautiously. This article reviews potential causes of a positive methacholine challenge other than asthma or RADS which are reported in medical literature. In cases of inhalation exposure evaluations, alternative explanations must be considered when determining whether a causal association exists between the exposure and a positive methacholine test result.
||literature survey; methacholine; allergy tests; asthma; diagnosis; inhalation
||obstructive ventilatory impairment; reliability; allergic reactivity; description of technique; hypersensitivity
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the respiratory system (except for pneumoconiosis & similar)