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CISDOC database

Document ID (ISN)108997
CIS number 08-1296
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2008
Convention or series no.
Author(s) Hewitt D.J.
Title Interpretation of the "positive" methacholine challenge
Bibliographic information Oct. 2008, Vol.51, No.10, p.769-781. Approx. 120 ref.
Abstract The methacholine challenge test is used in confirming the diagnosis of asthma, occupational asthma or reactive airways dysfunction syndrome (RADS) through the identification of bronchial hyperreactivity (BHR). While the sensitivity of the test in diagnosing clinically significant asthma is excellent, its specificity is poor. Since there are many conditions which have been associated with BHR, a positive test must be interpreted cautiously. This article reviews potential causes of a positive methacholine challenge other than asthma or RADS which are reported in medical literature. In cases of inhalation exposure evaluations, alternative explanations must be considered when determining whether a causal association exists between the exposure and a positive methacholine test result.
Descriptors (primary) literature survey; methacholine; allergy tests; asthma; diagnosis; inhalation
Descriptors (secondary) obstructive ventilatory impairment; reliability; allergic reactivity; description of technique; hypersensitivity
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)