| Document ID (ISN) | 108890 |
| CIS number |
08-1321 |
| Year |
2008 |
| Convention or series no. |
HSE Research Report 601
|
| Author(s) |
Naylor S., Fishwick D., Bradshaw L., Barber C., Tate P., Elms J., Robinson E., Rawbone R., Curran A.
Health and Safety Executive |
| Title |
Irritancy and sensitisation |
| Bibliographic information |
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2008. vi, 62p. Illus. 20 ref. |
| Internet access |
http://www.hse.gov.uk/research/rrpdf/rr601.pdf [in English]
|
| Abstract |
The objective of this study was to document clinical differences between irritation and sensitization in the workplace, with a view to facilitating the diagnosis of cases of work-related respiratory disease. Until now, most clinical cases were assessed on the nature and duration of symptoms alone or in conjunction with simple measures of lung function and IgE testing. This study was particularly focused on determining whether irritation or sensitization in the workplace was associated with the workers' immune profile. It involved of 172 workers across five worksites, including 55 workers predominantly exposed to irritant chemicals (welders and metalworkers exposed to irritant gases), 76 workers predominantly exposed to sensitizers (workers exposed to latex and insect allergens) and 41 non-exposed office workers. Clinical tests were carried out to allow immune profile, lung function, airway responsiveness and reported respiratory symptoms to be compared between worker groups. Findings are discussed. |
| Descriptors (primary) |
occupational diseases; irritation; symptoms; sensitization; individual susceptibility; medical examinations; respiratory diseases |
| Descriptors (secondary) |
allergens; irritants; immunoglobulins; chemical industry; United Kingdom; report; welding and cutting; latex; sensitizers; diagnosis; immunological tolerance; respiratory function tests; medical treatment; natural rubber |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | United Kingdom |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar)
|
