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Document ID (ISN)108859
CIS number 08-1379
ISSN - Serial title 0339-6517 - Documents pour le médecin du travail
Year 2008
Convention or series no. DMT 114TF170
Author(s) Jacob S., Héry M., Stengel B.
Title Exposure to organic solvents - Risk of evolution of chronic renal diseases towards terminal renal insufficiency
Original title Exposition aux solvants organiques - Risque de progression des maladies rénales chroniques vers l'insuffisance rénale terminale [in French]
Bibliographic information June 2008, No.114, p.233-241. Illus. 33 ref.
Internet access$File/TF170.pdf [in French]
Abstract This article describes a retrospective cohort study involving 338 patients suffering from glomerular nephropathies for which biopsies were performed between 1994 and 2001, and who were followed up until 2004. Their exposures to solvents were evaluated by industrial hygienists on the basis of interview data. Terminal renal insufficiency (TRI) was defined either as the patient requiring dialysis or a glomerular filtration rate of less than 15mL/min per 1.73m2. The relative risks of TRI associated with solvents were estimated using Cox regression models. It was found that high solvent exposure levels were associated with twofold to fourfold higher TRI risks. Products or chemicals giving rise to the greatest risks were printing inks, fuels, toluene, xylene, petroleum products and acetone. The most exposed workers were mechanics and fitters, plumbers and welders. These findings highlight the importance of screening for glomerular diseases and increased medical supervision of workers exposed to solvents in occupational settings.
Descriptors (primary) chronic diseases; risk factors; organic solvents; renal diseases
Descriptors (secondary) petroleum products; dialysis; acetone; toluene; occupation disease relation; printing inks; renal insufficiency; fuels; diagnosis; xylene; hazard evaluation; exposure evaluation; cohort study; biopsy; job-exposure relation; statistical evaluation; medical supervision; France
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the kidney and the urinary system