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Document ID (ISN)108682
CIS number 08-1143
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 2008
Convention or series no. Fascicule 16-047-A-25
Author(s) Mégarbane B., Baud F.J.
Title Poisoning from alcohols (other than ethanol) and glycols
Original title Intoxication par les alcools (autres que l'éthanol) et les glycols [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 2nd Quarter 2008, No.159, 9p. Illus. 81 ref.
Abstract Poisonings from toxic alcohols or glycols are rare but potentially serious. The main clinical outcome is the occurrence of a metabolic acidosis, giving rise to Küssmaul's dyspnoea. Other more specific complications can also arise during more severe poisonings; ethylene glycol can cause acute renal insufficiency, while methanol can cause vision disorders leading to irreversible blindness. Treatment is based on the administration of an antidote such as fomepizol for blocking the metabolic transformation of alcohol into toxic products by alcohol dehydrogenase, along with symptomatic resuscitation measures and intravenous perfusions of sodium bicarbonate. In the most serious cases, haemodialysis should be systematically performed together with the antidote treatment.
Descriptors (primary) France; alcohols; health hazards; toxicology; aliphatic diols
Descriptors (secondary) poisoning; sodium bicarbonate; renal dysfunction; methanol; ethylene glycol; symptoms; dyspnoea; blindness; resuscitation; antidote treatment; short-term exposure; long-term exposure; medical treatment; dialysis; encyclopaedia; data sheet; criteria document; enzyme inhibition
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Glycols