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Document ID (ISN)108527
CIS number 08-1053
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2007
Convention or series no.
Author(s) Ulvestad B., Randem B.G., Andersson L., Ellingsen D.G., Barregard L.
Title Clara cell protein as a biomarker for lung epithelial injury in asphalt workers
Bibliographic information Oct. 2007, Vol.49, No.10, p.1073-1078. Illus. 20 ref.
Abstract This study investigated whether asphalt workers showed signs of lung epithelial injury as shown by increased Clara cell protein 16 (CC16) in serum after six months of exposure. Asphalt pavers, asphalt plant operators and engineers from a large Norwegian road construction and repair enterprise underwent lung function tests and blood sampling before the start and at the end of the road working season. Blood samples were analysed for concentration of CC16 and interleukin-6 (IL-6). After adjustment for smoking, pavers had a significantly larger increase in CC16 concentration after the season as compared with that of engineers and plant operators. Among pavers, changes in serum CC16 were correlated with those of IL-6. CC16 increases over the season in pavers and appears to be a useful biomarker for lung epithelial injury in exposed workers.
Descriptors (primary) road work; lung diseases; exposure tests; bitumen; respiratory diseases
Descriptors (secondary) Norway; interleukins; determination in blood; exposure evaluation; smoking
Document type D - Periodical articles
Country / State or ProvinceNorway; Sweden
Subject(s) Construction industry
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Road transportation
Biological monitoring