|Document ID (ISN)||108023|
|Convention or series no.
||HSE Research Report 408
||Cherry N.M., Durrington P.N., Mackness B., Mackness M.I., Smith A.E., Dipnall M., Povey A.C.
Health and Safety Executive
||Genetic variation in susceptibility to chronic effects of organophosphate exposure
||HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2005. x, 116p. Illus. 25 ref.
||http://www.hse.gov.uk/research/rrpdf/rr408.pdf [in English]
||A case-control study was carried out to investigate whether the ability to metabolize and detoxify organophosphorus compounds differed between sheep dippers with self-reported chronic ill-health (cases) and healthy dippers (referents) of similar age and with a similar dipping experience. A total of 175 cases and 235 controls were interviewed by a nurse and information on their current health and occupational history obtained. Blood samples were also taken, DNA was extracted and polymorphisms in genes associated with organophosphorus compound metabolism were determined. Cases were more likely to have at least one R allele at position 192 and both alleles of type LL at position 55 of the paraoxonase gene, and to have diazoxonase activity below the median. Other findings are discussed.
||neurotoxic effects; livestock rearing; state of health; chronic diseases; organophosphorus compounds
||metabolic detoxication; subjective assessment; United Kingdom; report; cytogenetic studies; enzyme activity; case-control study; length of exposure; determination in blood; DNA
||E - Books, reports, proceedings
|Country / State or Province||United Kingdom|
||Agriculture, fishing, animal husbandry
Toxic and dangerous substances
|Broad subject area(s)
Diseases of the nervous system