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Document ID (ISN)108023
CIS number 08-656
Year 2005
Convention or series no. HSE Research Report 408
Author(s) Cherry N.M., Durrington P.N., Mackness B., Mackness M.I., Smith A.E., Dipnall M., Povey A.C.
Health and Safety Executive
Title Genetic variation in susceptibility to chronic effects of organophosphate exposure
Bibliographic information HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2005. x, 116p. Illus. 25 ref.
Internet access http://www.hse.gov.uk/research/rrpdf/rr408.pdf [in English]
Abstract A case-control study was carried out to investigate whether the ability to metabolize and detoxify organophosphorus compounds differed between sheep dippers with self-reported chronic ill-health (cases) and healthy dippers (referents) of similar age and with a similar dipping experience. A total of 175 cases and 235 controls were interviewed by a nurse and information on their current health and occupational history obtained. Blood samples were also taken, DNA was extracted and polymorphisms in genes associated with organophosphorus compound metabolism were determined. Cases were more likely to have at least one R allele at position 192 and both alleles of type LL at position 55 of the paraoxonase gene, and to have diazoxonase activity below the median. Other findings are discussed.
Descriptors (primary) neurotoxic effects; livestock rearing; state of health; chronic diseases; organophosphorus compounds
Descriptors (secondary) metabolic detoxication; subjective assessment; United Kingdom; report; cytogenetic studies; enzyme activity; case-control study; length of exposure; determination in blood; DNA
Document type E - Books, reports, proceedings
Country / State or ProvinceUnited Kingdom
Subject(s) Agriculture, fishing, animal husbandry
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Livestock rearing
Diseases of the nervous system