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Document ID (ISN)107961
CIS number 08-391
ISSN - Serial title 0007-9952 - Cahiers de notes documentaires - Hygiène et sécurité du travail
Year 2007
Convention or series no. INRS ND 2272-208-07
Author(s) Robert A., Ducos P., Francin J.M., Marsan P.
Title Exposure to MDI in 19 French enterprises - Urinary MDA as a biomarker of exposure
Original title Exposition au MDI dans 19 entreprises françaises - La MDA urinaire comme biomarqueur de l'exposition [in French]
Bibliographic information 3rd Quarter 2007, No.208, p.7-17. Illus. 55 ref.
Abstract Animal experiments have proven that skin exposure to 4,4'- methylenediphenyl diisocyanate (MDI) causes respiratory allergies. It is therefore necessary to take skin exposure into account when evaluating exposure to MDI. Determination of 4,4'-methylenedianiline (MDA) in urine is considered to be a reliable method for evaluating exposure to MDI by all routes of entry. This study was aimed at evaluating the level of skin exposure to MDI in 19 French enterprises in various sectors of activity, my means of measuring the urinary excretion of MDA. Taking the existing technical and analytical capabilities into account, a biological limit of 7µg/L (5µg/g creatinine) for urinary MDA, not to be exceeded at the end of the shift, could be proposed.
Descriptors (primary) diphenylmethane diisocyanate; determination in urine; exposure tests; skin absorption
Descriptors (secondary) threshold limit values; methylenedianiline; public OSH institutions; routes of entry; France; sampling and analysis; allergies; respiratory diseases; exposure evaluation; case-control study; animal experiments; creatinine
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Isocyanates
Cyano compounds