| Document ID (ISN) | 107961 |
| CIS number |
08-391 |
| ISSN - Serial title |
0007-9952 - Cahiers de notes documentaires - Hygiène et sécurité du travail |
| Year |
2007 |
| Convention or series no. |
INRS ND 2272-208-07
|
| Author(s) |
Robert A., Ducos P., Francin J.M., Marsan P. |
| Title |
Exposure to MDI in 19 French enterprises - Urinary MDA as a biomarker of exposure |
| Original title |
Exposition au MDI dans 19 entreprises françaises - La MDA urinaire comme biomarqueur de l'exposition [in French] |
| Bibliographic information |
3rd Quarter 2007, No.208, p.7-17. Illus. 55 ref. |
| Abstract |
Animal experiments have proven that skin exposure to 4,4'- methylenediphenyl diisocyanate (MDI) causes respiratory allergies. It is therefore necessary to take skin exposure into account when evaluating exposure to MDI. Determination of 4,4'-methylenedianiline (MDA) in urine is considered to be a reliable method for evaluating exposure to MDI by all routes of entry. This study was aimed at evaluating the level of skin exposure to MDI in 19 French enterprises in various sectors of activity, my means of measuring the urinary excretion of MDA. Taking the existing technical and analytical capabilities into account, a biological limit of 7µg/L (5µg/g creatinine) for urinary MDA, not to be exceeded at the end of the shift, could be proposed. |
| Descriptors (primary) |
diphenylmethane diisocyanate; determination in urine; exposure tests; skin absorption |
| Descriptors (secondary) |
threshold limit values; methylenedianiline; public OSH institutions; routes of entry; France; sampling and analysis; allergies; respiratory diseases; exposure evaluation; case-control study; animal experiments; creatinine |
| Document type |
D - Periodical articles |
| Country / State or Province | France |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Cyano compounds
Biological monitoring
Isocyanates
|
