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Document ID (ISN)107745
CIS number 08-175
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 2006
Convention or series no. Fascicule 16-046-T-10
Author(s) Bard D.
Title Halogenated polycyclic aromatic hydrocarbons
Original title Hydrocarbures aromatiques polycycliques halogénés [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 4th Quarter 2006, No.153, 7p. Illus. 60 ref.
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or "Seveso dioxin" is the most toxic of all halogenated polycyclic aromatic hydrocarbons. Dioxins, together with similar families of products including polychlorodibenzofuranes (PCDFs) and polychlorobiphenyls (PCBs) have been grouped together to yield a single numerical value called the "toxic equivalent quantity" (TEQ) to characterize the potential toxicity of any environment where these congeneric substances are found. Non-carcinogenic effects are very diverse, the most reported and specific appearing at high doses. TCDD has been classified as a carcinogenic to humans in 1997. All persons are exposed daily to very low doses of dioxins, essentially through the ingestion of food. The form of the dose-response relationship for cancer remains uncertain. Several chemical industry worker cohort studies have yielded information allowing the modelling of the relationship, but the findings remain open to various interpretations.
Descriptors (primary) France; polychlorinated biphenyls; toxicology; dioxins; chlorinated dibenzofurans
Descriptors (secondary) toxic effects; criteria document; mutagens; antifertility effects; carcinogens; routes of entry; IARC; tetrachlorodibenzodioxin; epidemiology; toxic substances; hazard evaluation; animal experiments; in vitro experiments; dose-response relationship; encyclopaedia; data sheet; literature survey
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Halogenated hydrocarbons
Heterocyclic compounds