|Document ID (ISN)||107578|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Lee C.Y., Jung S.L., Kim S.A., Park K.S., Ha B.G.
||Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers
||Oct. 2006, Vol.63, No.10, p.688-693. Illus. 16 ref.
||The objective of this cohort was to investigate the incidence of N,N-dimethylacetamide (DMA)-induced hepatic injury among new elastane fibre workers and to explore risk factors relating to this injury. A total of 440 new workers employed from 1 January 2002 to 31 July 2004 were included as study subjects. DMA exposure estimates were based on urinary N-methylacetamide (NMA) concentrations. There were 28 cases of DMA-induced hepatic injury. The overall incidence of DMA induced hepatic injury among new elastane fibre workers was 0.089/person-year. Incidence rates were seven to ten times higher in high exposure groups than in low exposure groups. Results suggest the existence of a dose-dependent DMA-induced hepatic injury. The inverse relation between the incidence of DMA-induced hepatic injury and duration of employment may reflect a type of healthy worker effect or an acquired tolerance to DMA-induced hepatic injury.
||elastomers; dimethylacetamide; risk factors; Korea, Republic of; hepatic damage; chemical industry
||healthy worker effect; methylacetamide; tolerance; determination in urine; dose-response relationship; frequency rates; length of service
||D - Periodical articles
|Country / State or Province||Korea, Republic of|
||Chemicals, plastics and rubber
|Broad subject area(s)
Occupational medicine, epidemiology