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Document ID (ISN)107578
CIS number 08-70
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2006
Convention or series no.
Author(s) Lee C.Y., Jung S.L., Kim S.A., Park K.S., Ha B.G.
Title Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers
Bibliographic information Oct. 2006, Vol.63, No.10, p.688-693. Illus. 16 ref.
Abstract The objective of this cohort was to investigate the incidence of N,N-dimethylacetamide (DMA)-induced hepatic injury among new elastane fibre workers and to explore risk factors relating to this injury. A total of 440 new workers employed from 1 January 2002 to 31 July 2004 were included as study subjects. DMA exposure estimates were based on urinary N-methylacetamide (NMA) concentrations. There were 28 cases of DMA-induced hepatic injury. The overall incidence of DMA induced hepatic injury among new elastane fibre workers was 0.089/person-year. Incidence rates were seven to ten times higher in high exposure groups than in low exposure groups. Results suggest the existence of a dose-dependent DMA-induced hepatic injury. The inverse relation between the incidence of DMA-induced hepatic injury and duration of employment may reflect a type of healthy worker effect or an acquired tolerance to DMA-induced hepatic injury.
Descriptors (primary) elastomers; dimethylacetamide; risk factors; Korea, Republic of; hepatic damage; chemical industry
Descriptors (secondary) healthy worker effect; methylacetamide; tolerance; determination in urine; dose-response relationship; frequency rates; length of service
Document type D - Periodical articles
Country / State or ProvinceKorea, Republic of
Subject(s) Chemicals, plastics and rubber
Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Liver diseases
Amides
Chemical industry