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Document ID (ISN)107556
CIS number 08-66
ISSN - Serial title 0019-8366 - Industrial Health
Year 2007
Convention or series no.
Author(s) Bianchi C., Bianchi T.
Title Malignant mesothelioma: Global incidence and relationship with asbestos
Bibliographic information June 2007, Vol.45, No.3, p.379-387. Illus. 89 ref.
Abstract Literature survey. Mesothelioma incidence varies markedly from one country to another. The areas of high incidence generally correspond to the sites of industries with high asbestos use, such as shipbuilding and asbestos-cement industry. However, in some countries with high asbestos consumption, mesothelioma incidence is low. The reasons for this situation are not clear. Mesotheliomas generally develop after long-time exposures to asbestos and with latency periods of often more than 40 years. An inverse relationship exists between intensity of asbestos exposure and the length of the latency period. Some recent studies show that the risk increases with the duration of exposure. Possible co-factors in the pathogenesis of asbestos-related mesothelioma include genetic predisposition, diets poor in fruit and vegetables, some viruses, immune impairment and recurrent pleural inflammation. While a levelling-off in mesothelioma incidence has been registered in some countries, a worsening of the epidemic is predictable in large parts of the world.
Descriptors (primary) mesothelioma; frequency rates; risk factors; asbestos
Descriptors (secondary) literature survey; asbestos cement; latency; diet; pleural diseases; job-exposure relation; immunity; shipbuilding industry; length of exposure; dose-response relationship; virus diseases
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Viral diseases (other than aids)
Bacterial and parasitic diseases