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CISDOC database

Document ID (ISN)107464
CIS number 07-1253
ISBN(s) 978-3-7776-1531-8
Year 2007
Convention or series no. BUA Report 265
Advisory Committee on Existing Chemicals (BUA)
Title 2-Chlorobenzonitrile; 4-chlorobenzonitrile
Bibliographic information S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2007. xiv, 48p. 121 ref. Price: EUR 00.00. Downloadable version free of charge.
Internet access [in English]
Abstract Conclusions of this criteria document which reflects the state of knowledge of April 2006: the toxicity of 2-chlorobenzonitrile and 4-chlorobenzonitrile are low. In rats, the oral LD5l0 for 2-chlorobenzonitrile and 4-chlorobenzonitrile are 396mg and 887mg per kg body weight respectively. For 2-chlorobenzonitrile, the 4h LC50 in rats is more than 440mg/m3 and the dermal LD5l0 in rabbits is between 340 and 600 mg/kg body weight. No corresponding data are available for 4-chlorobenzonitrile. In mutagenicity tests, 2-chlorobenzonitrile is non-mutagenic up to the cytotoxic range. No data on mutagenicity are available for 4-chlorobenzonitrile. No data for either substance are available for an evaluation of the sensitization potential, genotoxicity, carcinogenicity and reproductive toxicity.
Descriptors (primary) toxic effects; Germany; ecotoxicology; nitriles; chlorinated organic compounds
Descriptors (secondary) literature survey; criteria document; animal experiments
Document type B - Chemical safety information sheets
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Cyano compounds
Pollution control