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CISDOC database

Document ID (ISN)107463
CIS number 07-1252
ISBN(s) 978-3-7776-1530-1
Year 2007
Convention or series no. BUA Report 262
Advisory Committee on Existing Chemicals (BUA)
Title Isopropylisocyanate
Bibliographic information S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2007. xiv, 40p. 79 ref. Price: EUR 00.00. Downloadable version free of charge.
Internet access [in English]
Abstract Conclusions of this criteria document which reflects the state of knowledge of November 2005: isopropyl isocyanate is highly irritating to the skin, eyes and respiratory tract. In male rats, the 5h LC50 is 499mg/m3 and the oral LD5l0 is 218mg/kg body weight in rats. Animal studies at high concentrations show adverse effects on the respiratory function. In mutagenicity tests, the product is non-mutagenic up to the toxic range. No data are available for an evaluation of the sensitization potential, genotoxicity, carcinogenicity and reproductive toxicity.
Descriptors (primary) toxic effects; ecotoxicology; isopropyl isocyanate; Germany
Descriptors (secondary) literature survey; criteria document; animal experiments; irritants
Document type B - Chemical safety information sheets
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Pollution control
Cyano compounds