|Document ID (ISN)||107463|
|Convention or series no.
||BUA Report 262
Advisory Committee on Existing Chemicals (BUA)
||S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2007. xiv, 40p. 79 ref. Price: EUR 00.00. Downloadable version free of charge.
||http://www.dav-buchhandlung.de/... [in English]
||Conclusions of this criteria document which reflects the state of knowledge of November 2005: isopropyl isocyanate is highly irritating to the skin, eyes and respiratory tract. In male rats, the 5h LC50 is 499mg/m3 and the oral LD5l0 is 218mg/kg body weight in rats. Animal studies at high concentrations show adverse effects on the respiratory function. In mutagenicity tests, the product is non-mutagenic up to the toxic range. No data are available for an evaluation of the sensitization potential, genotoxicity, carcinogenicity and reproductive toxicity.
||toxic effects; ecotoxicology; isopropyl isocyanate; Germany
||literature survey; criteria document; animal experiments; irritants
||B - Chemical safety information sheets
|Country / State or Province||Germany|
||Toxic and dangerous substances
|Broad subject area(s)