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Document ID (ISN)107445
CIS number 07-1379
ISSN - Serial title 0962-7480 - Occupational Medicine
Year 2006
Convention or series no.
Author(s) Hannu T., Alanko K., Keskinen H.
Title Anaphylaxis and allergic contact urticaria from occupational airborne exposure to HBTU
Bibliographic information 2006, No.56, p.430-433. Illus. 16 ref.
Abstract This article describes a case of anaphylaxis and allergic contact urticaria from occupational airborne exposure to HBTU (o-benzotriazol-1-yl-tetramethyluronium hexafluorophosphate), which is a chemical used widely for solid and solution-phase peptide synthesis, in a laboratory technician. There have been previous reports of this chemical being been associated with occupational asthma, allergic contact urticaria and allergic contact dermatitis in individual cases, but not with anaphylaxis. The diagnosis was based on clinical symptoms, a positive skin prick test (SPT) and a positive skin provocation test to HBTU. The positive SPT indicates that the anaphylaxis reaction is IgE-mediated. Appropriate safety measures should be compulsory when handling HBTU, and if work-related symptoms develop, the possibility of anaphylaxis should be considered.
Descriptors (primary) allergens; laboratory work; hypersensitivity; urticaria; eczema
Descriptors (secondary) immunoglobulins; public OSH institutions; case study; Finland; peptides; medical examinations; asthma; change of employment; diagnosis; limitation of exposure; skin tests; symptoms
Document type D - Periodical articles
Country / State or ProvinceFinland
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases