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Document ID (ISN)107426
CIS number 07-1318
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2007
Convention or series no.
Author(s) Pisati G., Baruffini A., Bernabeo F., Cerri S., Mangili A.
Title Rechallenging subjects with occupational asthma due to toluene diisocyanate (TDI), after long-term removal from exposure
Bibliographic information Feb. 2007, Vol.80, No.4, p.298-305. Illus. 21 ref.
Abstract The aims of this study were to determine whether toluene diisocyanate (TDI) bronchial hyperresponsiveness persists in subjects with occupational asthma after long cessation of exposure and whether evolution of specific bronchial TDI sensitization and symptoms and functional abnormalities of asthma were coincident, and to define the determinants at the time of diagnosis of patients' outcome. Twenty-five non-atopic spray painters with occupational asthma due to TDI were re-examined approximately five years after removal from exposure. Tests included spirometry, methacholine challenge and TDI-specific IgE. Seven subjects were still TDI-reactors while 18 had lost reactivity to the substance, among whom however eight still retained some asthma features. This study demonstrates that airway sensitization to TDI and symptoms and functional airway abnormalities of asthma can persist for years after cessation of exposure.
Descriptors (primary) chronic bronchitis; tolylene diisocyanate; asthma; sensitization; risk factors; hypersensitivity; paint spraying
Descriptors (secondary) immunoglobulins; methacholine; symptoms; serological reactions; allergy tests; spirometry; transfer to other work; long-term study
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Surface treatment