|Document ID (ISN)||107426|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Pisati G., Baruffini A., Bernabeo F., Cerri S., Mangili A.
||Rechallenging subjects with occupational asthma due to toluene diisocyanate (TDI), after long-term removal from exposure
||Feb. 2007, Vol.80, No.4, p.298-305. Illus. 21 ref.
||The aims of this study were to determine whether toluene diisocyanate (TDI) bronchial hyperresponsiveness persists in subjects with occupational asthma after long cessation of exposure and whether evolution of specific bronchial TDI sensitization and symptoms and functional abnormalities of asthma were coincident, and to define the determinants at the time of diagnosis of patients' outcome. Twenty-five non-atopic spray painters with occupational asthma due to TDI were re-examined approximately five years after removal from exposure. Tests included spirometry, methacholine challenge and TDI-specific IgE. Seven subjects were still TDI-reactors while 18 had lost reactivity to the substance, among whom however eight still retained some asthma features. This study demonstrates that airway sensitization to TDI and symptoms and functional airway abnormalities of asthma can persist for years after cessation of exposure.
||chronic bronchitis; tolylene diisocyanate; asthma; sensitization; risk factors; hypersensitivity; paint spraying
||immunoglobulins; methacholine; symptoms; serological reactions; allergy tests; spirometry; transfer to other work; long-term study
||D - Periodical articles
|Country / State or Province||Italy|
||Chemicals, plastics and rubber
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the respiratory system (except for pneumoconiosis & similar)