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Document ID (ISN)107274
CIS number 07-1369
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) Sennbro C.J., Lindh C.H., Mattsson C., J÷nsson B.A.G., Tinnerberg H.
Title Biological monitoring of exposure to 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate
Bibliographic information Sep. 2006, Vol.79, No.8, p.647-653. Illus. 28 ref.
Abstract Biological monitoring of exposure to occupational sensitizers, such as 1,5-naphthalene diisocyanate (NDI) and 4,4'-methylenediphenyl diisocyanate (MDI) is of high importance. In this study, the breathing atmosphere exposure to NDI and MDI was monitored for 30 workers at four different plants. In parallel, urinary as well as blood plasma samples were collected. 1,5-naphthalenediamine (NDA) and 4,4'-methylenedianiline (MDA) in hydrolysed urine and plasma were evaluated as biomarkers of exposure to NDI and MDI, respectively, by means of gas chromatography-mass spectrometry. Air exposure to both MDI and NDI was correlated to their corresponding biomarkers, but with a large individual variation.
Descriptors (primary) diphenylmethane diisocyanate; exposure tests; naphthylene diisocyanate
Descriptors (secondary) methylenedianiline; mass spectrometry; 1,5-naphthalenediamine; reliability; exposure evaluation; determination in urine; determination in air; determination in blood; description of technique; gas chromatography; sampling and analysis
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Isocyanates
Cyano compounds