| Document ID (ISN) | 107274 |
| CIS number |
07-1369 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2006 |
| Convention or series no. |
|
| Author(s) |
Sennbro C.J., Lindh C.H., Mattsson C., Jönsson B.A.G., Tinnerberg H. |
| Title |
Biological monitoring of exposure to 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate |
| Bibliographic information |
Sep. 2006, Vol.79, No.8, p.647-653. Illus. 28 ref. |
| Abstract |
Biological monitoring of exposure to occupational sensitizers, such as 1,5-naphthalene diisocyanate (NDI) and 4,4'-methylenediphenyl diisocyanate (MDI) is of high importance. In this study, the breathing atmosphere exposure to NDI and MDI was monitored for 30 workers at four different plants. In parallel, urinary as well as blood plasma samples were collected. 1,5-naphthalenediamine (NDA) and 4,4'-methylenedianiline (MDA) in hydrolysed urine and plasma were evaluated as biomarkers of exposure to NDI and MDI, respectively, by means of gas chromatography-mass spectrometry. Air exposure to both MDI and NDI was correlated to their corresponding biomarkers, but with a large individual variation. |
| Descriptors (primary) |
diphenylmethane diisocyanate; exposure tests; naphthylene diisocyanate |
| Descriptors (secondary) |
methylenedianiline; mass spectrometry; 1,5-naphthalenediamine; reliability; exposure evaluation; determination in urine; determination in air; determination in blood; description of technique; gas chromatography; sampling and analysis |
| Document type |
D - Periodical articles |
| Country / State or Province | Sweden |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Cyano compounds
Biological monitoring
Isocyanates
|
