ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)107254
CIS number 07-1365
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2006
Convention or series no.
Author(s) Valberg P.A., Long C.M., Sax S.N.
Title Integrating studies on carcinogenic risk of carbon black: Epidemiology, animal exposures, and mechanism of action
Bibliographic information Dec. 2006, Vol.48, No.12, p.1291-1307. 76 ref.
Abstract In this literature survey on the toxicology of carbon black (CB), epidemiology and laboratory studies were reviewed from 1996, when IARC classified carbon black as a group 2B carcinogen (probably carcinogenic to humans). Findings are discussed. High levels of inhaled CB were linked with rat lung tumours in 1996, but today scientists increasingly recognize that rats exhibit a unique lung tumour response to all inert inhaled particles that is unlikely to be relevant to humans. Toxicity in rats results from the particle overload, and not from the particles' chemistry. Research published after 1996 has not identified an increase in support for CB cancer risk, but rather, points to limited and inadequate evidence for carcinogenicity. Overall, the new epidemiological evidence decreases concerns for cancer risk compared with pre-1996 evidence.
Descriptors (primary) lung cancer; risk factors; carbon black
Descriptors (secondary) literature survey; carcinogens; animal experiments; toxicology; epidemiology; IARC
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)