|Document ID (ISN)||107073|
|Convention or series no.
||BUA Report 264
Advisory Committee on Existing Chemicals (BUA)
||S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiv, 58p. 136 ref.
||Conclusions of this criteria document which reflects the state of knowledge of February 2006: 4-chlorophenyl-isocyanate is a colourless to yellowish solid which melts below 30░C. It is highly-reactive chemical intermediate used in the production of certain plant protection chemicals. It hydrolyses in the presence of water, forming 4-chloroaniline. Modes of entry include ingestion, inhalation and skin absorption. The few available animal studies show low toxicity but with inconsistent results. There are no data on chronic ingestion toxicity. In rats, the target organ of chronic inhalation exposure is the lung. It is irritating to the skin and eye. In vitro studies show the product to be non-mutagenic. There are no data on reproductive toxicity and carcinogenicity.
||agricultural chemicals; 4-chlorophenyl isocyanate; ecotoxicology; isocyanates; toxicology; Germany
||literature survey; irritants; routes of entry; criteria document; animal experiments; in vitro experiments; skin absorption
||B - Chemical safety information sheets
|Country / State or Province||Germany|
||Toxic and dangerous substances
|Broad subject area(s)