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CISDOC database

Document ID (ISN)107073
CIS number 07-1007
ISBN(s) 978-3-7776-1507-3
Year 2006
Convention or series no. BUA Report 264
Author(s)
Advisory Committee on Existing Chemicals (BUA)
Title 4-Chlorophenyl-isocyanate
Bibliographic information S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiv, 58p. 136 ref.
Abstract Conclusions of this criteria document which reflects the state of knowledge of February 2006: 4-chlorophenyl-isocyanate is a colourless to yellowish solid which melts below 30░C. It is highly-reactive chemical intermediate used in the production of certain plant protection chemicals. It hydrolyses in the presence of water, forming 4-chloroaniline. Modes of entry include ingestion, inhalation and skin absorption. The few available animal studies show low toxicity but with inconsistent results. There are no data on chronic ingestion toxicity. In rats, the target organ of chronic inhalation exposure is the lung. It is irritating to the skin and eye. In vitro studies show the product to be non-mutagenic. There are no data on reproductive toxicity and carcinogenicity.
Descriptors (primary) agricultural chemicals; 4-chlorophenyl isocyanate; ecotoxicology; isocyanates; toxicology; Germany
Descriptors (secondary) literature survey; irritants; routes of entry; criteria document; animal experiments; in vitro experiments; skin absorption
Document type B - Chemical safety information sheets
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Pollution control
Isocyanates
Cyano compounds
Agricultural chemicals