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CISDOC database

Document ID (ISN)107056
CIS number 07-1113
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) Di Lorenzo L., Silvestroni A., Martino M.G., Gagliardi T., Corfiati M., Soleo L.
Title Evaluation of peripheral blood neutrophil leucocytes in lead-exposed workers
Bibliographic information June 2006, Vol.79, No.6, p.491-498. 44 ref.
Abstract The objective of this study was to verify whether occupational lead exposure induces changes in the number of blood neutrophil leucocytes, and to assess a possible dose-response relationship between blood lead (Pb-B) and the circulating neutrophil count in exposed workers. It involved 68 lead-exposed male workers and 59 unexposed male controls. A standardized questionnaire on occupational and non-occupational factors was administered to all the subjects. Blood and urine samples were collected and analysed. Compared to controls, exposed workers had significantly higher Pb-B and mean absolute neutrophil count (ANC). ANC correlated significantly with the biological lead dose and effect indices. Moreover, there was a dose-dependent increase of ANC with increasing Pb-B levels. There was also an interaction between Pb-B level and smoking habit in increasing the number of blood neutrophils among lead-exposed workers.
Descriptors (primary) leukocytes; exposure tests; neutrophil changes; lead and compounds
Descriptors (secondary) non-occupational factors; blood count; lead; smoking; determination in urine; case-control study; dose-response relationship; determination in blood; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Lead and compounds
Inorganic substances
Biological monitoring