|Document ID (ISN)||107056|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Di Lorenzo L., Silvestroni A., Martino M.G., Gagliardi T., Corfiati M., Soleo L.
||Evaluation of peripheral blood neutrophil leucocytes in lead-exposed workers
||June 2006, Vol.79, No.6, p.491-498. 44 ref.
||The objective of this study was to verify whether occupational lead exposure induces changes in the number of blood neutrophil leucocytes, and to assess a possible dose-response relationship between blood lead (Pb-B) and the circulating neutrophil count in exposed workers. It involved 68 lead-exposed male workers and 59 unexposed male controls. A standardized questionnaire on occupational and non-occupational factors was administered to all the subjects. Blood and urine samples were collected and analysed. Compared to controls, exposed workers had significantly higher Pb-B and mean absolute neutrophil count (ANC). ANC correlated significantly with the biological lead dose and effect indices. Moreover, there was a dose-dependent increase of ANC with increasing Pb-B levels. There was also an interaction between Pb-B level and smoking habit in increasing the number of blood neutrophils among lead-exposed workers.
||leukocytes; exposure tests; neutrophil changes; lead and compounds
||non-occupational factors; blood count; lead; smoking; determination in urine; case-control study; dose-response relationship; determination in blood; questionnaire survey
||D - Periodical articles
|Country / State or Province||Italy|
||Toxic and dangerous substances
|Broad subject area(s)
Lead and compounds