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Document ID (ISN)107054
CIS number 07-1112
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) Fernández-Nieto M., Quirce S., Carnés J., Sastre J.
Title Occupational asthma due to chromium and nickel salts
Bibliographic information June 2006, Vol.79, No.6, p.483-486. 16 ref.
Abstract Exposure to chromium and nickel salts is a poorly characterized cause of occupational asthma. This article describes four patients with work-related asthma due to metallic salts. Skin tests to potassium dichromate and nickel sulfate were performed. The patients also underwent methacholine inhalation tests and specific inhalation challenges (SIC) with chromium and nickel salts. Two patients showed positive skin tests to potassium dichromate and nickel sulfate. All patients had bronchial hyperresponsiveness to methacholine, which increased 24h after SIC with metallic salts. SIC with potassium dichromate elicited late asthmatic reactions in two workers, one subject had an early asthmatic reaction, and another subject showed a dual asthmatic reaction. SIC with nickel sulfate induced a dual asthmatic reaction in one subject and a late asthmatic reaction in another. Chromium and nickel salts can give rise to occupational asthma in exposed workers. The underlying mechanism may be IgE-mediated.
Descriptors (primary) allergens; chromium and compounds; asthma; nickel and compounds
Descriptors (secondary) immunoglobulins; case study; nickel sulfate; potassium dichromate; symptoms; allergy tests; skin tests; methacholine
Document type D - Periodical articles
Country / State or ProvinceSpain
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Nickel and compounds
Inorganic substances