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CISDOC database

Document ID (ISN)107023
CIS number 07-1109
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2005
Convention or series no.
Author(s) Wennborg H., Magnusson L.L., Bonde J.P., Olsen J.
Title Congenital malformations related to maternal exposure to specific agents in biomedical research laboratories
Bibliographic information Jan. 2005, Vol.47, No.1, p.11-19. Illus. 48 ref.
Abstract The objective of this study was to evaluate the frequency of major congenital and neural crest malformations in the offspring of laboratory employees. It involved 3003 births among 1951 Swedish women laboratory workers. Exposure information was based on questionnaires, allowing women to be classified as being highly or weakly exposed. Odds ratios (ORs) were calculated. The prevalences of major malformations were 2.3% among highly exposed women and 1.9% among weakly exposed women. ORs were 1.8 for solvent exposure before the third trimester, 1.2 for laboratory work in general and 5.3 for benzene exposure around the time of conception. No significant risk for laboratory work in general was seen, but there was an increased risk relative to exposures to solvents, especially benzene. These results are based on small numbers and should be interpreted cautiously.
Descriptors (primary) parental exposure; laboratory work; women; teratogenic effects; solvents
Descriptors (secondary) Sweden; benzene; expectant mothers; cohort study; teratogens
Document type D - Periodical articles
Country / State or ProvinceDenmark; Sweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects