|Document ID (ISN)||106918|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Kezic S., Meuling W.J.A., Jakasa I.
||Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers
||Nov. 2004, Vol.77, No.8, p.580-586. Illus. 18 ref.
||http://www.springerlink.com/content/1hnb9mtxtl85d5hx/fulltext.pdf [in English]
||To assess excretion kinetics of free and total 2-butoxyacetic acid (BAA) following dermal and inhalation exposure to 2-butoxyethanol (BE), six male volunteers were dermally-exposed for 4h to a 50% aqueous BE on the forearm. Six other male volunteers were exposed by inhalation (mouth only) to 93mg/m3 BE for 30min. As biological indices of exposure, BE in blood and total and free BAA in urine were measured. Findings are discussed. Overall, inter-individual variability was large. However, due to lower inter-individual variability, total BAA was found to be superior to free BAA as a biomarker of both cutaneous and inhalation exposures to BE.
||butoxyethanol; exposure tests; butoxyacetic acid
||inhalation; skin absorption; determination in urine; human experiments; determination in blood; exposure evaluation
||D - Periodical articles
|Country / State or Province||Netherlands|
||Toxic and dangerous substances
|Broad subject area(s)