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Document ID (ISN)106918
CIS number 07-865
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2004
Convention or series no.
Author(s) Kezic S., Meuling W.J.A., Jakasa I.
Title Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers
Bibliographic information Nov. 2004, Vol.77, No.8, p.580-586. Illus. 18 ref.
Internet access http://www.springerlink.com/content/1hnb9mtxtl85d5hx/fulltext.pdf [in English]
Abstract To assess excretion kinetics of free and total 2-butoxyacetic acid (BAA) following dermal and inhalation exposure to 2-butoxyethanol (BE), six male volunteers were dermally-exposed for 4h to a 50% aqueous BE on the forearm. Six other male volunteers were exposed by inhalation (mouth only) to 93mg/m3 BE for 30min. As biological indices of exposure, BE in blood and total and free BAA in urine were measured. Findings are discussed. Overall, inter-individual variability was large. However, due to lower inter-individual variability, total BAA was found to be superior to free BAA as a biomarker of both cutaneous and inhalation exposures to BE.
Descriptors (primary) butoxyethanol; exposure tests; butoxyacetic acid
Descriptors (secondary) inhalation; skin absorption; determination in urine; human experiments; determination in blood; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Glycol ethers