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Document ID (ISN)106737
CIS number 07-647
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2006
Convention or series no.
Author(s) Filon F.L., Boeniger M., Maina G., Adami G., Spinelli P., Damian A.
Title Skin absorption of inorganic lead (PbO) and the effect of skin cleansers
Bibliographic information July 2006, Vol.48, No.7, p.692-699. Illus. 40 ref.
Abstract The aim of this study was to investigate the percutaneous penetration of lead oxide (PbO) powder and the effect of two different detergents on the speed of skin decontamination. Franz cells were used to study in vitro PbO skin penetration during a 24h period. The tests were performed without or with decontamination using either a common brand of liquid soap or a new experimental cleanser 30 minutes after the start of exposure. It was confirmed that PbO can pass through the skin with a median penetration of 2.9ng/cm2. The cleaning procedure using the liquid soap significantly increased skin penetration with a median value of 23.6ng/cm2, whereas the new experimental cleanser only marginally increased penetration (7.1ng/cm2). The results indicate that it is necessary to prevent skin contamination from occurring in the first place because a short contact can increase skin penetration even if quickly followed by washing.
Descriptors (primary) skin contamination; airborne dust; skin cleansers; skin absorption; lead oxide
Descriptors (secondary) skin protection
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Skin protection
Lead and compounds
Inorganic substances