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Document ID (ISN)106736
CIS number 07-646
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2006
Convention or series no.
Author(s) Ernstgård L., Iregren A., Sjögren B., Svedberg U., Johanson G.
Title Acute effects of exposure to hexanal vapors in humans
Bibliographic information June 2006, Vol.48, No.6, p.573-580. Illus. 24 ref.
Abstract n-Hexanal is a major component in emissions from stored wood pellets. The production and use of wood pellets as a source of renewable energy is increasing rapidly. The aim of this study was to evaluate acute health effects of n-hexanal vapours. Twelve healthy volunteers were exposed to 0, 2 and 10ppm n-hexanal for two hours at rest. Ratings of discomfort in the eyes and nose, solvent smell and headache increased significantly with the level of exposure. Frequency of blinking was significantly increased at 10ppm. No effects on pulmonary function and nasal swelling were detected, except a non-significant tendency to increased nasal obstruction at 10ppm. No clear effects on plasma inflammatory markers (C-reactive protein and interleukin-6) were observed. It is concluded that two hours of exposure to n-hexanal results in mild irritation at 10ppm, with no apparent adversity at 2ppm.
Descriptors (primary) n-hexanal; health hazards; toxicity evaluation; wood and wood products
Descriptors (secondary) irritants; subjective assessment; dose-response relationship; symptoms; migraine
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aldehydes