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Document ID (ISN)106555
CIS number 07-505
ISBN(s) 92-4-153067-7
Year 2005
Convention or series no. CICAD No.67
Author(s) Copestake P.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
Title Selected alkoxyethanols - 2-Butoxyethanol
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2005. iv, 51p. Illus. Approx. 180 ref.
Internet access [in English]
Abstract This criteria document on 2-butoxyethanol is an update of the earlier edition published in 1998 (see CIS 04-262). Human health aspects have been extensively revised on the basis of recent data on carcinogenicity and modes of action. 2-Butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer. The main effect exerted by 2-butoxyethanol and its metabolite 2-butoxyacetic acid is haematotoxicity, with the rat being the most sensitive species. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. Long-term studies in laboratory animals show some evidence of carcinogenicity in mice. Based on the haemolytic effects observed on pregnant rats exposed during gestation, a revised tolerable concentration of 11.0mg/m3 has been derived. Detailed summaries in French and Spanish are included.
Descriptors (primary) toxic effects; toxicology; butoxyethanol; IPCS
Descriptors (secondary) literature survey; threshold limit values; irritants; ILO; UNEP; WHO; criteria document; ecotoxicology; animal experiments; in vitro experiments; haematotoxic effects; carcinogenic effects; butoxyacetic acid
Document type B - Chemical safety information sheets
Country / State or ProvinceWHO
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Glycol ethers