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Document ID (ISN)106541
CIS number 07-618
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2006
Convention or series no.
Author(s) Tovalin H., Valverde M., Morandi M.T., Blanco S., Whitehead L., Rojas E.
Title DNA damage in outdoor workers occupationally exposed to environmental air pollutants
Bibliographic information Apr. 2006, Vol.63, No.4, p.230-236. Illus. 40 ref.
Abstract Health concerns about exposure to genotoxic and carcinogenic agents in the air are particularly significant for outdoor workers in cities of developing countries where air pollution levels are high. This study was undertaken to evaluate the association between personal exposure to volatile organic compounds, particulate matter with mass mean diameter ≥2.5Ám (PM2.5) and ozone, and the severity of DNA damage in outdoor workers from two Mexican cities. DNA damage (comet assay) and personal exposure were investigated in 55 outdoor and indoor workers from Mexico City and Puebla. Outdoor workers had greater DNA damage, reflected by a longer tail length, than indoor workers. DNA damage magnitude was positively correlated with PM2.5 and ozone exposure. Workers with ≥60% of highly damaged cells had significantly higher exposures to PM2.5, ozone and certain volatile organic compounds, namely 1-ethyl-2-methyl benzene.
Descriptors (primary) toxic effects; Mexico; atmospheric pollution; outdoor work; DNA
Descriptors (secondary) carcinogens; personal sampling; ozone; volatile substances; 1,2-ethylmethylbenzene; aerosols; breathing atmosphere; determination in air; respirable dust
Document type D - Periodical articles
Country / State or ProvinceMexico; USA
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Environmental pollution
Air pollution