|Document ID (ISN)||106537|
|ISSN - Serial title
||0962-7480 - Occupational Medicine
|Convention or series no.
||Povey A.C., Mackness M.I., Durrington P.N., Dippnall M., Smith A.E., Mackness B., Cherry N.M.
||Paraoxonase polymorphisms and self-reported chronic ill-health in farmers dipping sheep
||June 2005, Vol.55, No.4, p.282-286. 27 ref.
||Serum paraoxonase (PON1) provides protection against organophosphate-induced toxicity. It has been reported that the frequency of paraoxonase polymorphisms in sheep dippers with self-reported chronic ill-health differed from that in dippers with no self-reported ill-health. The aim of this study was to examine whether the risk associated with PON1 polymorphisms varied using homogenous case and referent populations. Each subject completed a detailed symptom questionnaire and their general practitioner was asked whether there was any history of neurological disease that could be confused with the effects of organophosphate poisoning. Some subjects were then excluded both on clinical grounds and where identified as atypical on discriminant analysis. Risk associated with the PON1 192 and 55 genotypes altered little with these changes in the population. These findings support the hypothesis that organophosphates contribute to the self-reported ill-health of sheep dippers.
||livestock rearing; state of health; organophosphorus compounds
||subjective assessment; enzymes; exposure evaluation; individual susceptibility; case-control study; long-term exposure; questionnaire survey
||D - Periodical articles
|Country / State or Province||Canada; United Kingdom|
||Agriculture, fishing, animal husbandry
|Broad subject area(s)