ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)106537
CIS number 07-653
ISSN - Serial title 0962-7480 - Occupational Medicine
Year 2005
Convention or series no.
Author(s) Povey A.C., Mackness M.I., Durrington P.N., Dippnall M., Smith A.E., Mackness B., Cherry N.M.
Title Paraoxonase polymorphisms and self-reported chronic ill-health in farmers dipping sheep
Bibliographic information June 2005, Vol.55, No.4, p.282-286. 27 ref.
Abstract Serum paraoxonase (PON1) provides protection against organophosphate-induced toxicity. It has been reported that the frequency of paraoxonase polymorphisms in sheep dippers with self-reported chronic ill-health differed from that in dippers with no self-reported ill-health. The aim of this study was to examine whether the risk associated with PON1 polymorphisms varied using homogenous case and referent populations. Each subject completed a detailed symptom questionnaire and their general practitioner was asked whether there was any history of neurological disease that could be confused with the effects of organophosphate poisoning. Some subjects were then excluded both on clinical grounds and where identified as atypical on discriminant analysis. Risk associated with the PON1 192 and 55 genotypes altered little with these changes in the population. These findings support the hypothesis that organophosphates contribute to the self-reported ill-health of sheep dippers.
Descriptors (primary) livestock rearing; state of health; organophosphorus compounds
Descriptors (secondary) subjective assessment; enzymes; exposure evaluation; individual susceptibility; case-control study; long-term exposure; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceCanada; United Kingdom
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Livestock rearing